Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22057992 | 0.79 | KCNH2 (0.37) | NOS2AKT2KCNH2LMNAAPEX1 | |
| SCHEMBL19602949 | 0.74 | NOS2 (0.38) | NOS2AKT2KCNH2LMNAAPEX1 | |
| SCHEMBL20334165 | 0.73 | — | — | |
| SCHEMBL6344963 | 0.72 | — | — | |
| SCHEMBL84454 | 0.69 | — | — | |
| SCHEMBL10864351 | 0.68 | AKT1 (0.44) | NOS2AKT2KCNH2AKT1 | |
| Hydrochloric Acid SCHEMBL20897673 | 0.68 | — | — | |
| SCHEMBL23031949 | 0.66 | KCNH2 (0.42) | NOS2AKT2KCNH2LMNAAPEX1 | |
| SCHEMBL18291459 | 0.66 | KCNH2 (0.42) | NOS2AKT2KCNH2LMNAAPEX1 | |
| SCHEMBL24868068 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148132-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |