Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22966751 | 0.93 | ROCK2 (0.61) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL21217861 | 0.93 | ROCK2 (0.61) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL22967219 | 0.93 | ROCK2 (0.61) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL21217523 | 0.85 | ROCK2 (0.58) | ROCK2ROCK1MEN1KMT2ASMYD3 | |
| SCHEMBL21217525 | 0.83 | ROCK2 (0.58) | ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL22966755 | 0.83 | ROCK2 (0.59) | ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL22966736 | 0.82 | ROCK1 (0.51) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL22966753 | 0.81 | ROCK2 (0.50) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL22966735 | 0.80 | ROCK2 (0.49) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL24094396 | 0.80 | ROCK2 (0.53) | ROCK2ROCK1MEN1KMT2ASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |
| WO-2019145729-A9 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2020-07-30 | — | — | WO | disclosed |
| WO-2019145729-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2019-08-01 | — | — | WO | disclosed |