Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.54 |
| ▸ | AXL | P30530 | 5/20 | 0.53 |
| ▸ | MET | P08581 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26178850 | 0.88 | AXL (0.62) | KDRPDGFRAAXLMETAURKA | |
| SCHEMBL21200981 | 0.80 | AXL (0.81) | KDRAXLMETAURKALCK | |
| SCHEMBL12663554 | 0.80 | AXL (0.60) | KDRPDGFRAAXLMETAURKA | |
| SCHEMBL22106609 | 0.79 | AXL (0.70) | KDRPDGFRAAXLMETAURKA | |
| SCHEMBL1890635 | 0.76 | AXL (0.65) | KDRPDGFRAAXLMETAURKA | |
| SCHEMBL29558136 | 0.76 | AXL (0.65) | KDRPDGFRAAXLMETAURKA | |
| SCHEMBL12663553 | 0.76 | KDR (0.59) | KDRPDGFRAAXLMETAURKA | |
| SCHEMBL12501921 | 0.75 | AXL (0.62) | KDRPDGFRAAXLMETAURKA | |
| SCHEMBL12663608 | 0.73 | AXL (0.54) | KDRPDGFRAAXLMETAURKA | |
| SCHEMBL2173553 | 0.73 | AXL (0.63) | KDRPDGFRAAXLMETAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148044-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |