Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21218475 | 0.78 | IKBKB (0.39) | CRBN | |
| SCHEMBL21218400 | 0.76 | CRBN (0.53) | CRBNMAPT | |
| SCHEMBL21218476 | 0.76 | CRBN (0.47) | DYRK1ACRBN | |
| SCHEMBL21218164 | 0.75 | DYRK1A (0.47) | DYRK1ACRBN | |
| SCHEMBL21218410 | 0.72 | DYRK1A (0.36) | DYRK1ACRBN | |
| SCHEMBL21218399 | 0.71 | CRBN (0.47) | DYRK1ACRBN | |
| SCHEMBL21218363 | 0.69 | CRBN (0.50) | CRBN | |
| SCHEMBL21218359 | 0.69 | BRD4 (0.39) | CRBN | |
| SCHEMBL25924559 | 0.68 | CRBN (0.60) | DYRK1ACRBN | |
| SCHEMBL25218039 | 0.66 | DYRK1A (0.44) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019147783-A1 | SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-01 | — | — | WO | disclosed |