Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.53 |
| ▸ | ACLY | P53396 | 6/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CCR4 | P51679 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389171 | 0.87 | CRBN (0.59) | CRBNACLYGLO1SLC40A1PTGES2 | |
| SCHEMBL26844443 | 0.87 | CRBN (0.61) | CRBNACLYCCR1CCR2CCR4 | |
| SCHEMBL21218353 | 0.79 | CRBN (0.51) | CRBNACLYCCR1CCR2CCR4 | |
| SCHEMBL21218374 | 0.77 | CRBN (0.80) | CRBNACLYCCR1CCR2CCR4 | |
| SCHEMBL3060786 | 0.77 | CRBN (0.71) | CRBNACLYGLO1SLC40A1PTGES2 | |
| SCHEMBL24762246 | 0.76 | CRBN (0.53) | CRBNACLYGLO1SLC40A1RXFP1 | |
| SCHEMBL21218405 | 0.76 | DYRK1A (0.33) | CRBNMAPT | |
| SCHEMBL21218180 | 0.75 | CRBN (0.78) | CRBNACLYCCR1CCR2CCR4 | |
| SCHEMBL24762053 | 0.75 | CRBN (0.68) | CRBNACLYCCR1CCR2CCR4 | |
| SCHEMBL26844497 | 0.74 | CRBN (0.74) | CRBNACLYCCR1CCR2CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807606-B2 | Sulfonamide derivatives for protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20200290964-A1 | SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. | 2020-09-17 | — | — | US | disclosed |
| WO-2019147783-A1 | SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200290964-A1 | SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION | CUL5, CUL4A, DCAF1 | CRBN 14/4885ACLY 2332/4885CCR1 3189/4885 |
| US-11807606-B2 | Sulfonamide derivatives for protein degradation | CUL5, CUL4A, DCAF1 | CRBN 14/4885ACLY 2332/4885CCR1 3189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.