Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 4/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 9/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2121997 | 0.90 | GLO1 (0.63) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL2141897 | 0.88 | ALK (0.47) | LRRK2GSK3AAURKAAURKBCDC7 | |
| SCHEMBL2122295 | 0.86 | GLO1 (0.46) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL2121349 | 0.85 | GLO1 (0.50) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL2124535 | 0.82 | GLO1 (0.56) | GLO1GSK3AAURKBCDC7ALK | |
| SCHEMBL2141375 | 0.78 | ALK (0.52) | GLO1LRRK2GSK3AMAPK8CDC7 | |
| SCHEMBL2123441 | 0.78 | ALK (0.55) | GLO1LRRK2ALKFLT3ROS1 | |
| SCHEMBL2124283 | 0.76 | GLO1 (0.52) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL10074538 | 0.76 | GLO1 (0.55) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL656107 | 0.74 | GLO1 (0.78) | GLO1LRRK2GSK3AMAPK15CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172384-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2012-07-05 | — | — | US | claimed |
| EP-2443106-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | Cellzome Limited (GB) | 2012-04-25 | — | — | EP | claimed |
| WO-2010146133-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2010-12-23 | — | — | WO | claimed |
| US-20120172384-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2012-07-05 | — | — | US | disclosed |
| EP-2443106-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | Cellzome Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010146133-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172384-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | ZAP70, JAK3, JAK2 | GLO1 3371/4885LRRK2 1177/4885GSK3A 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.