Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.76 |
| ▸ | CTRL | P40313 | 2/20 | 0.76 |
| ▸ | PSMB5 | P28074 | 14/20 | 0.75 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.75 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.75 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.75 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.75 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.75 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.75 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.75 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.75 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.75 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.75 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.75 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.75 |
| ▸ | CTSB | P07858 | 1/20 | 0.75 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.75 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629505 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL21229438 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL10083436 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL17629503 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL19762063 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL23616283 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL17452274 | 0.95 | CTRL (0.70) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL20825236 | 0.93 | CTRL (0.74) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL18257499 | 0.93 | CTRL (0.74) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL21367483 | 0.93 | CTRL (0.74) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329325-B2 | Process for the preparation of (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxo-pentan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamide | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD (IN) | 2019-06-25 | — | — | US | disclosed |
| US-20170298093-A1 | Process for the Preparation of (S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-YL)-1-OXO Pentan-2-YL) Amino)-1-OXO-3-Phenylpropan-2-YL)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido) Pentanamide | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD (IN) | 2017-10-19 | — | — | US | disclosed |
| WO-2016185450-A1 | AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LAURUS LABS PRIVATE LIMITED (IN) | 2016-11-24 | — | — | WO | disclosed |
| US-20090105156-A1 | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides | PROTEOLIX, INC. (US) | 2009-04-23 | — | — | US | disclosed |
| WO-2009045497-A1 | CRYSTALLINE PEPTIDE EPOXY KETONE PROTEASE INHIBITORS AND THE SYNTHESIS OF AMINO ACID KETO-EPOXIDES | PROTEOLIX, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298093-A1 | Process for the Preparation of (S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-YL)-1-OXO Pentan-2-YL) Amino)-1-OXO-3-Phenylpropan-2-YL)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido) Pentanamide | PSMA1, PSMA2, PSMA6 | TMPRSS11D 574/4885CTRL 17/4885PSMB5 23/4885 |
| US-10329325-B2 | Process for the preparation of (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxo-pentan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamide | PSMA1, PSMA2, PSMA3 | TMPRSS11D 654/4885CTRL 20/4885PSMB5 25/4885 |
| US-20090105156-A1 | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides | PREP, ANPEP, DNPEP | TMPRSS11D 158/4885CTRL 74/4885PSMB5 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.