Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21230173 | 0.94 | ALDH1A1 (0.39) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL21230117 | 0.87 | ALDH1A1 (0.38) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL19151672 | 0.86 | ALDH1A1 (0.39) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL8109881 | 0.85 | HDAC4 (0.33) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL3249605 | 0.81 | ALDH1A1 (0.49) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL3250456 | 0.78 | HDAC6 (0.43) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL3244594 | 0.78 | ALDH1A1 (0.46) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL3262869 | 0.77 | HDAC4 (0.50) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL18867357 | 0.77 | NPC1 (0.47) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL3247527 | 0.77 | HDAC6 (0.42) | HDAC4HDAC1HDAC6HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311813-B1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2019-08-07 | — | — | EP | disclosed |