Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29346987 | 0.93 | CYP4F2 (0.54) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL20475488 | 0.91 | PKM (0.47) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL21233486 | 0.87 | CYP4F2 (0.47) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL4774435 | 0.87 | PKM (0.45) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL21225833 | 0.85 | CYP4F2 (0.46) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL4767476 | 0.85 | PKM (0.45) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL21963889 | 0.84 | PKM (0.47) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL2797888 | 0.84 | CYP4F2 (0.44) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL4792775 | 0.84 | PKM (0.44) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 | |
| SCHEMBL2799709 | 0.83 | PKM (0.47) | CYP4F2CYP4A11PKMUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112204031-A | Spiro-lactam NMDA receptor modulators and uses thereof | 阿普廷伊克斯股份有限公司 | 2021-01-08 | — | — | CN | disclosed |
| WO-2019152687-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |