Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18711886 | 0.90 | OTUD7B (0.46) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL2728185 | 0.85 | OTUD7B (0.38) | JAK1TYK2HSD17B10OTUD7BLTA4H | |
| SCHEMBL21225565 | 0.83 | CRBN (0.35) | OTUD7BHPGDLTA4HCCNCCDK8 | |
| SCHEMBL21224568 | 0.80 | OTUD7B (0.37) | JAK1TYK2GAAOTUD7BLTA4H | |
| SCHEMBL2020246 | 0.79 | CCNC (0.44) | MEN1KMT2AUSP2MAPK1HPGD | |
| SCHEMBL2605421 | 0.79 | OTUD7B (0.41) | JAK2JAK1TYK2JAK3OTUD7B | |
| SCHEMBL19852842 | 0.78 | OTUD7B (0.45) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL13207170 | 0.76 | JAK2 (0.40) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL25238524 | 0.75 | OTUD7B (0.37) | OTUD7BLTA4HGRIN1GRIN2A | |
| SCHEMBL5173578 | 0.75 | OTUD7B (0.37) | OTUD7BLTA4HGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11578072-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | APTINYX INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-20210040095-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2021-02-11 | — | — | US | disclosed |
| WO-2019152687-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11578072-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | GRIN1, GRIN2A, GRIN2B | JAK2 3631/4885JAK1 4460/4885TYK2 2835/4885 |
| US-20210040095-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | GRIN1, GRIN2A, GRIN2B | JAK2 3631/4885JAK1 4460/4885TYK2 2835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.