Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1637367 | 0.88 | CXCR4 (0.64) | KMT2AMEN1CXCR4ALDH1A1TSHR | |
| SCHEMBL2124123 | 0.87 | MEN1 (0.46) | KMT2AMEN1CXCR4ALDH1A1TSHR | |
| SCHEMBL1638046 | 0.85 | KMT2A (0.45) | KMT2AMEN1CXCR4ALDH1A1TSHR | |
| SCHEMBL5795105 | 0.81 | KMT2A (0.42) | KMT2AMEN1CXCR4ALDH1A1TSHR | |
| SCHEMBL369262 | 0.79 | TSHR (0.45) | KMT2AMEN1CXCR4ALDH1A1TSHR | |
| SCHEMBL2124334 | 0.79 | MEN1 (0.40) | KMT2AMEN1CXCR4ALDH1A1TSHR | |
| SCHEMBL1206400 | 0.79 | CXCR4 (0.48) | KMT2AMEN1CXCR4ALDH1A1TSHR | |
| SCHEMBL1637273 | 0.73 | CXCR4 (0.72) | KMT2AMEN1CXCR4TSHRLMNA | |
| SCHEMBL1637097 | 0.73 | CXCR4 (0.72) | KMT2AMEN1CXCR4TSHRLMNA | |
| SCHEMBL1637100 | 0.73 | CXCR4 (0.72) | KMT2AMEN1CXCR4TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476290-B2 | Compound having spiro-bonded cyclic group and use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120101280-A1 | COMPOUND HAVING SPIRO-BONDED CYCLIC GROUP AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-04-26 | — | — | US | disclosed |
| EP-2444402-A1 | COMPOUND HAVING SPIRO-BONDED CYCLIC GROUP AND USE THEREOF | ONO Pharmaceutical Co., Ltd. (JP) | 2012-04-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101280-A1 | COMPOUND HAVING SPIRO-BONDED CYCLIC GROUP AND USE THEREOF | CXCR4, CXCL12, CCR5 | KMT2A 4122/4885MEN1 2741/4885CXCR4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.