Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 19/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.76 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.76 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.76 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.70 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869013 | 0.86 | EIF2AK3 (1.00) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL23042872 | 0.83 | EIF2AK3 (0.70) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL870782 | 0.82 | EIF2AK3 (1.00) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL868058 | 0.82 | EIF2AK3 (0.74) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL868275 | 0.82 | EIF2AK3 (0.77) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL868281 | 0.82 | EIF2AK3 (0.74) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL869403 | 0.79 | EIF2AK3 (0.75) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL868916 | 0.78 | EIF2AK3 (0.64) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL2373988 | 0.78 | EIF2AK3 (0.64) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL868814 | 0.77 | EIF2AK3 (1.00) | EIF2AK3CYP3A4EIF2AK2EIF2AK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11759437-B2 | Preventive and therapeutic approach for aberrant cell differentiation and ISR-associated diseases | THE UNIVERSITY OF HONG KONG (CN) | 2023-09-19 | — | — | US | disclosed |
| US-11759437-B2 | Preventive and therapeutic approach for aberrant cell differentiation and ISR-associated diseases | THE UNIVERSITY OF HONG KONG (CN) | 2023-09-19 | — | — | US | disclosed |
| US-20190240171-A1 | PREVENTIVE AND THERAPEUTIC APPROACH FOR ABERRANT CELL DIFFERENTIATION AND ISR-ASSOCIATED DISEASES | UNIV HONG KONG (CN) | 2019-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240171-A1 | PREVENTIVE AND THERAPEUTIC APPROACH FOR ABERRANT CELL DIFFERENTIATION AND ISR-ASSOCIATED DISEASES | ATF4, EIF6, DDIT3 | EIF2AK3 4/4885CYP3A4 4800/4885EIF2AK2 12/4885 |
| US-11759437-B2 | Preventive and therapeutic approach for aberrant cell differentiation and ISR-associated diseases | ATF4, EIF6, DDIT3 | EIF2AK3 4/4885CYP3A4 4800/4885EIF2AK2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.