Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | GBA2 | Q9HCG7 | 10/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23603291 | 0.88 | SIGMAR1 (0.44) | SIGMAR1GBA2GAAGBA1 | |
| SCHEMBL19274956 | 0.87 | SIGMAR1 (0.47) | SIGMAR1GBA2GBA1 | |
| SCHEMBL22564948 | 0.81 | OGA (0.41) | SIGMAR1GBA2GAAGBA1 | |
| SCHEMBL25141784 | 0.81 | GBA2 (0.45) | GBA2GAAGBA1 | |
| SCHEMBL4892211 | 0.78 | GBA2 (0.54) | GBA2GAAGBA1 | |
| SCHEMBL4893528 | 0.78 | GBA2 (0.54) | GBA2GAAGBA1 | |
| SCHEMBL4885572 | 0.78 | GBA2 (0.54) | GBA2GAAGBA1 | |
| SCHEMBL22309125 | 0.77 | GAA (0.40) | SIGMAR1GAAGBA1 | |
| SCHEMBL9801706 | 0.76 | SIGMAR1 (0.45) | SIGMAR1 | |
| SCHEMBL20093581 | 0.75 | GBA1 (0.58) | GBA2GAAGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968316-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |