Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 5/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19522879 | 1.00 | HTT (0.36) | HTTMAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL21025210 | 0.88 | MMP12 (0.45) | HTTMAPTKDM4ETDP1MMP12 | |
| SCHEMBL18430215 | 0.87 | SCN10A (0.42) | HTTMAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL5526838 | 0.80 | MAPT (0.42) | HTTMAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL20032424 | 0.79 | MAPT (0.39) | HTTMAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL23718965 | 0.77 | MAPT (0.40) | HTTMAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL21284894 | 0.77 | MAPT (0.40) | HTTMAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL21152556 | 0.77 | MAPT (0.40) | HTTMAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL21266994 | 0.77 | MAPT (0.40) | HTTMAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL5404733 | 0.77 | MAPT (0.40) | HTTMAPTKDM4EALDH1A1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968316-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |