Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 4/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | ROS1 | P08922 | 2/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.40 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2125825 | 0.91 | GLO1 (0.51) | GLO1LRRK2EGFRALKROS1 | |
| SCHEMBL2123461 | 0.91 | GLO1 (0.59) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL2122067 | 0.88 | GLO1 (0.55) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL2121049 | 0.85 | GLO1 (0.62) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL2123175 | 0.84 | GLO1 (0.63) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL656107 | 0.83 | GLO1 (0.78) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL2123700 | 0.80 | ALK (0.57) | LRRK2EGFRALKROS1MET | |
| SCHEMBL1707645 | 0.80 | GLO1 (0.73) | GLO1LRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL2124145 | 0.79 | ALK (0.53) | GLO1LRRK2EGFRALKROS1 | |
| Hydrochloric Acid SCHEMBL1707850 | 0.79 | GLO1 (0.72) | GLO1LRRK2GSK3AMAPK15CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172384-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2012-07-05 | — | — | US | claimed |
| EP-2443106-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | Cellzome Limited (GB) | 2012-04-25 | — | — | EP | claimed |
| WO-2010146133-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2010-12-23 | — | — | WO | claimed |
| US-20120172384-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2012-07-05 | — | — | US | disclosed |
| EP-2443106-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | Cellzome Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010146133-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172384-A1 | HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS | ZAP70, JAK3, JAK2 | GLO1 3371/4885LRRK2 1177/4885GSK3A 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.