Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24408380 | 0.84 | NPC1 (0.41) | SCN10AHRH3 | |
| SCHEMBL24222036 | 0.78 | APP (0.40) | SCN10A | |
| SCHEMBL21240890 | 0.76 | SCN10A (0.41) | SCN10A | |
| SCHEMBL22277247 | 0.75 | MCHR1 (0.45) | SCN10A | |
| SCHEMBL22607179 | 0.74 | NPC1 (0.44) | HRH3 | |
| SCHEMBL16009648 | 0.69 | PIK3CD (0.30) | — | |
| SCHEMBL6685021 | 0.69 | RIPK1 (0.40) | HRH3 | |
| SCHEMBL26246006 | 0.69 | DYRK1A (0.36) | — | |
| SCHEMBL24222034 | 0.68 | POLB (0.35) | — | |
| SCHEMBL6683706 | 0.66 | HRH3 (0.46) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968316-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |