Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 2/20 | 0.56 |
| ▸ | KDM4B | O94953 | 2/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.56 |
| ▸ | KDM5C | P41229 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MPL | P40238 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22971499 | 0.91 | KDM4A (0.57) | KDM4AKDM4BKDM5BKDM5CCYP3A4 | |
| SCHEMBL21225354 | 0.88 | KDM4A (0.59) | KDM4AKDM4BKDM5BKDM5CMAPT | |
| SCHEMBL21225263 | 0.87 | KDM4A (0.62) | KDM4AKDM4BKDM5BKDM5CCYP3A4 | |
| SCHEMBL21241970 | 0.87 | KDM4A (0.56) | KDM4AKDM4BKDM5BKDM5CCYP3A4 | |
| SCHEMBL25502151 | 0.85 | MAPT (0.50) | KDM4AKDM4BKDM5BKDM5CCYP3A4 | |
| SCHEMBL22971566 | 0.84 | MPL (0.51) | CYP3A4ROCK1MPLROCK2 | |
| SCHEMBL25108373 | 0.83 | KDM4A (0.56) | KDM4AKDM4BKDM5BKDM5CCYP3A4 | |
| SCHEMBL30058865 | 0.83 | MEN1 (0.51) | KDM4AKDM4BKDM5BKDM5CCYP3A4 | |
| SCHEMBL23704982 | 0.83 | MEN1 (0.51) | KDM4AKDM4BKDM5BKDM5CCYP3A4 | |
| SCHEMBL23705010 | 0.82 | MAPT (0.47) | KDM4AKDM4BKDM5BKDM5CCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230072658-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-03-09 | — | — | US | disclosed |
| US-20210038611-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2021-02-11 | — | — | US | disclosed |
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | KDM4A 2166/4885KDM4B 1679/4885KDM5B 1944/4885 |
| US-20210038611-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | KDM4A 2166/4885KDM4B 1679/4885KDM5B 1944/4885 |
| US-20230072658-A1 | SMARCA DEGRADERS AND USES THEREOF | SMARCA1, SMARCB1, SMARCE1 | KDM4A 278/4885KDM4B 354/4885KDM5B 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.