Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.76 |
| ▸ | JAK2 | O60674 | 19/20 | 0.76 |
| ▸ | TYK2 | P29597 | 17/20 | 0.76 |
| ▸ | JAK3 | P52333 | 11/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21242546 | 0.87 | JAK1 (1.00) | JAK1JAK2TYK2JAK3CYP2C9 | |
| SCHEMBL24799653 | 0.74 | JAK2 (0.79) | JAK1JAK2TYK2JAK3CYP2C9 | |
| SCHEMBL21242551 | 0.72 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23424173 | 0.69 | JAK1 (0.75) | JAK1JAK2TYK2JAK3CYP2C9 | |
| SCHEMBL21242957 | 0.68 | JAK1 (0.68) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21242548 | 0.65 | JAK1 (0.83) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL13031549 | 0.65 | JAK1 (0.74) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21242550 | 0.65 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21242547 | 0.64 | JAK1 (1.00) | JAK1JAK2TYK2JAK3CYP2C19 | |
| SCHEMBL21242560 | 0.64 | JAK1 (1.00) | JAK1JAK2TYK2JAK3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019149244-A1 | JAK INHIBITOR AND USE THEREOF | 南京明德新药研发股份有限公司 | 2019-08-08 | — | — | WO | disclosed |