Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.47 |
| ▸ | CDC25C | P30307 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14588679 | 0.89 | CNR2 (0.52) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL1515779 | 0.83 | NR4A1 (0.52) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL14620600 | 0.82 | CDC25B (0.46) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL27794823 | 0.81 | CDC25B (0.50) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL18652132 | 0.80 | NR4A1 (0.52) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL10407111 | 0.79 | NR4A1 (0.59) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL3624003 | 0.78 | OPRM1 (0.56) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| Hydrochloric Acid SCHEMBL11683665 | 0.77 | NR4A1 (0.56) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL12984879 | 0.77 | SMPD2 (0.44) | CDC25BNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL28713330 | 0.76 | CDC25B (0.49) | CDC25BNR4A1NR4A2NR4A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842424-A1 | MAP KINASE MODULATORS AND USES THEREOF IN THE TRETAMENT OF TAUOPATHIES | The Trustees of Columbia University in the City of New York (US) | 2021-06-30 | — | — | EP | disclosed |
| EP-3521284-A1 | PYRAZINE COMPOUNDS AS MAP KINASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2019-08-07 | — | — | EP | disclosed |