Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | PAM | P19021 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217571 | 0.94 | ALDH1A1 (0.77) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| Propionic Acid SCHEMBL31077917 | 0.93 | ALDH1A1 (0.65) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| Acetic Acid SCHEMBL31078051 | 0.92 | ALDH1A1 (0.69) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| Hydrochloric Acid SCHEMBL29901825 | 0.92 | ALDH1A1 (0.74) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| Bicarbonate SCHEMBL23001581 | 0.92 | ALDH1A1 (0.74) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| Cyclopropane SCHEMBL29003079 | 0.89 | ALDH1A1 (0.69) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL1871761 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL111605 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| Stearic Acid SCHEMBL2118619 | 0.83 | MEN1 (0.54) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| Hydrochloric Acid SCHEMBL27438937 | 0.82 | ALDH1A1 (0.66) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190248864-A1 | POLYNUCLEOTIDES ENCODING LOW DENSITY LIPOPROTEIN RECEPTOR | MODERNATX, INC. | 2019-08-15 | — | — | US | disclosed |