Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30612380 | 0.96 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL27362176 | 0.94 | ALDH1A1 (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL20689356 | 0.90 | TYK2 (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL21258632 | 0.90 | TYK2 (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL21238865 | 0.90 | TYK2 (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL20697316 | 0.90 | TYK2 (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL21227547 | 0.90 | TYK2 (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL21258413 | 0.89 | TYK2 (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL20689219 | 0.89 | TYK2 (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL18161062 | 0.89 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230056447-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-02-23 | — | — | US | disclosed |
| US-10562906-B2 | TYK2 inhibitors and uses thereof | Nimbus Lakshimi, Inc. (US) | 2020-02-18 | — | — | US | disclosed |
| US-20190241576-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10562906-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | KDM4E 391/4885ALDH1A1 4827/4885SMN1; SMN2 1145/4885 |
| US-20190241576-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | KDM4E 391/4885ALDH1A1 4827/4885SMN1; SMN2 1145/4885 |
| US-20230056447-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | KDM4E 391/4885ALDH1A1 4827/4885SMN1; SMN2 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.