Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | APEX1 | P27695 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL28690611 | 0.97 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28547005 | 0.97 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL25232333 | 0.97 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29018761 | 0.97 | LMNA (0.67) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL1052165 | 0.97 | LMNA (0.67) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28115454 | 0.91 | CYP3A4 (0.59) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL25432181 | 0.90 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL8471781 | 0.89 | CYP3A4 (0.72) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL22645159 | 0.89 | CYP3A4 (0.72) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL2445125 | 0.88 | LMNA (0.71) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118177310-A | Biomass-based food fresh-keeping spray and preparation method thereof | 陕西科技大学 | 2024-06-14 | — | — | CN | claimed |
| CN-118166055-A | Crayfish shell ACE (angiotensin converting enzyme) inhibitory peptide and preparation method and application thereof | 湖北工业大学 | 2024-06-11 | — | — | CN | claimed |
| CN-118063815-A | Preparation method and application of functional composite film containing lignin extract | 中山大学附属第三医院 | 2024-05-24 | — | — | CN | claimed |
| CN-117986649-A | Method for plasticizing cassava starch film by using low-co-solvent | 青岛科技大学 | 2024-05-07 | — | — | CN | claimed |
| CN-117945383-A | Method for preparing carbon micro-tube by DES and ionic liquid | 广西大学 | 2024-04-30 | — | — | CN | claimed |
| CN-117886961-A | Method for extracting slug polysaccharide by ultrasonic-assisted eutectic solvent | 广西壮族自治区中国科学院广西植物研究所 | 2024-04-16 | — | — | CN | claimed |
| CN-117845058-A | Method for recycling indium and tin from ITO waste target | 云南大学 | 2024-04-09 | — | — | CN | claimed |
| CN-117384303-A | Preparation method of high-stability oxidized regenerated bean dreg cellulose nanocrystalline | 中国农业科学院农产品加工研究所 | 2024-01-12 | — | — | CN | claimed |
| CN-113088542-B | Biomass pretreatment process and solvent recovery method used in treatment process thereof | 淮阴师范学院 | 2023-10-24 | — | — | CN | claimed |
| WO-2023170106-A1 | AN ELECTROCHEMICAL PROCESS FOR RECOVERING PLATINUM GROUP METALS (PGMs) FROM SOLID RESIDUES | FUNDACION TECNALIA RESEARCH & INNOVATION (ES) | 2023-09-14 | — | — | WO | claimed |
| CN-110627783-A | Preparation method of Schiff base containing carbazolyl and oxadiazolyl or thiadiazolyl | 陕西科技大学 | 2019-12-31 | — | — | CN | claimed |
| CN-106928055-B | A method of aspirin is catalyzed and synthesized using choline eutectic solvent | 南阳理工学院 | 2019-11-29 | — | — | CN | claimed |
| CN-110358923-A | A method of indium is extracted using zinc oxide fumes and recycles zinc oxide fumes | 昆明理工大学 | 2019-10-22 | — | — | CN | claimed |
| CN-110357145-A | A method of zinc oxalate is prepared using zinc oxide fumes and prepares nano zine oxide | 昆明理工大学 | 2019-10-22 | — | — | CN | claimed |
| CN-106749805-B | A kind of atom transfer radical polymerization method acted on using low temperature eutectic | 华中科技大学 | 2019-07-09 | — | — | CN | claimed |
| CN-109627148-A | A kind of preparation method of cannabidiol, cannabidiol obtained and application thereof | 中国农业科学院麻类研究所 | 2019-04-16 | — | — | CN | claimed |
| CN-108864242-A | The extracting process of ursolic acid and application | 中国农业科学院麻类研究所 | 2018-11-23 | — | — | CN | claimed |
| CN-105274598-B | The preparation method of electro-deposition room temperature n-type BiTeSe thermoelectric films in ionic liquid | 天津农学院 | 2017-08-11 | — | — | CN | claimed |
| CN-106928055-A | A kind of method that use choline eutectic solvent catalyzes and synthesizes aspirin | 南阳理工学院 | 2017-07-07 | — | — | CN | claimed |
| CN-106749805-A | A kind of atom transfer radical polymerization method of utilization low temperature eutectic effect | 华中科技大学 | 2017-05-31 | — | — | CN | claimed |