Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 15/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21248737 | 1.00 | JAK3 (0.47) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL31302340 | 0.89 | JAK3 (0.47) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL31302453 | 0.89 | JAK3 (0.47) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL31302338 | 0.89 | JAK3 (0.47) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL21248793 | 0.85 | PIM1 (0.45) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL21248794 | 0.85 | PIM1 (0.45) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL16522625 | 0.81 | CTSK (0.46) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL16525753 | 0.81 | CTSK (0.46) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL24456502 | 0.80 | PIM1 (0.49) | JAK3BTKSUV39H2CTSKCKS1B | |
| SCHEMBL17965894 | 0.80 | CKS1B (0.49) | JAK3BTKSUV39H2CTSKCKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752498-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019157458-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2019-08-15 | — | — | WO | disclosed |