Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 13/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.59 |
| ▸ | DRD1 | P21728 | 5/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | HTR3B | O95264 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL142391 | 0.89 | CHRM1 (0.75) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL21258181 | 0.87 | CHRM1 (0.66) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL13389257 | 0.86 | DRD2 (0.79) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL30543472 | 0.86 | DRD2 (0.79) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL21258180 | 0.81 | DRD2 (0.63) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL21258032 | 0.78 | DRD2 (0.57) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL7801315 | 0.78 | DRD2 (0.76) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL21248527 | 0.78 | DRD2 (0.56) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL21248506 | 0.78 | DRD2 (0.56) | HRH4DRD2CHRM1DRD1DRD4 | |
| SCHEMBL21258175 | 0.78 | DRD2 (0.56) | HRH4DRD2CHRM1DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3749325-B1 | DREADD ACTUATORS | US HEALTH (US) | 2026-04-08 | — | — | EP | disclosed |
| US-11739063-B2 | DREADD actuators | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-08-29 | — | — | US | disclosed |
| US-20200399228-A1 | DREADD ACTUATORS | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-12-24 | — | — | US | disclosed |
| EP-3749325-A1 | DREADD ACTUATORS | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019157083-A1 | DREADD ACTUATORS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11739063-B2 | DREADD actuators | GRK1, GRK3, GRK2 | HRH4 392/4885DRD2 373/4885CHRM1 32/4885 |
| US-20200399228-A1 | DREADD ACTUATORS | GRK1, GRK3, GRK2 | HRH4 392/4885DRD2 373/4885CHRM1 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.