Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 6/20 | 0.34 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.33 |
| ▸ | CSF1R | P07333 | 3/20 | 0.33 |
| ▸ | LYN | P07948 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | BLK | P51451 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24322401 | 0.83 | NOS2 (0.44) | PDPK1GAACLK4ROCK1CDK5 | |
| SCHEMBL2660353 | 0.72 | PDPK1 (0.47) | PDPK1GAACLK4ROCK1CDK5 | |
| SCHEMBL22757498 | 0.70 | ESR2 (0.38) | FLT3CDK2 | |
| SCHEMBL15818464 | 0.69 | KDR (0.45) | PDPK1GAACLK4ROCK1CDK5 | |
| SCHEMBL16680879 | 0.69 | PDPK1 (0.46) | PDPK1GAACLK4ROCK1CDK5 | |
| SCHEMBL16680722 | 0.69 | GAA (0.53) | PDPK1GAACLK4ROCK1CDK5 | |
| SCHEMBL22349055 | 0.69 | GAA (0.53) | PDPK1GAACLK4ROCK1CDK5 | |
| SCHEMBL25702368 | 0.69 | KDR (0.42) | PDPK1GAACLK4ROCK1CDK5 | |
| SCHEMBL11749905 | 0.69 | JAK2 (0.42) | PDPK1GAACLK4ROCK1CDK5 | |
| SCHEMBL24854354 | 0.69 | PDPK1 (0.38) | PDPK1GAACLK4ROCK1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377743-B2 | Inhibitors of RAS and methods of use thereof | ARAXES PHARMA LLC (US) | 2019-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10377743-B2 | Inhibitors of RAS and methods of use thereof | KRAS, NRAS, HRAS | PDPK1 1340/4885GAA 1372/4885CLK4 3368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.