Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 7/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | WHR1 | P49842 | 2/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240381 | 0.95 | PDE9A (0.40) | HPGDALDH1A1HIF1ANTSR1PDE9A | |
| SCHEMBL30044646 | 0.95 | PDE9A (0.40) | HPGDALDH1A1HIF1ANTSR1PDE9A | |
| SCHEMBL20331745 | 0.89 | PDE9A (0.37) | HPGDALDH1A1HIF1ANTSR1PDE9A | |
| SCHEMBL29577448 | 0.89 | PDE9A (0.37) | HPGDALDH1A1HIF1ANTSR1PDE9A | |
| SCHEMBL29578031 | 0.85 | MAP4K1 (0.33) | HPGDALDH1A1HIF1ANTSR1PDE9A | |
| SCHEMBL20331493 | 0.85 | MAP4K1 (0.33) | HPGDALDH1A1HIF1ANTSR1PDE9A | |
| SCHEMBL30045784 | 0.85 | PDE9A (0.41) | HPGDALDH1A1HIF1ANTSR1PDE9A | |
| SCHEMBL20332262 | 0.85 | PDE9A (0.41) | HPGDALDH1A1HIF1ANTSR1PDE9A | |
| SCHEMBL21252194 | 0.84 | PIK3CA (0.36) | HPGDALDH1A1HIF1ANTSR1KDM4E | |
| SCHEMBL30045467 | 0.81 | SMN1; SMN2 (0.51) | HPGDALDH1A1HIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |