Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | WHR1 | P49842 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 6/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252150 | 0.94 | MAP3K12 (0.33) | PIK3CAMTORKDM4ESTAT6NPSR1 | |
| SCHEMBL21252311 | 0.90 | MAP4K1 (0.33) | PIK3CAMTORKDM4ESTAT6NPSR1 | |
| SCHEMBL21251799 | 0.89 | PIK3CA (0.36) | PIK3CAMTORKDM4ESTAT6NPSR1 | |
| SCHEMBL30044646 | 0.89 | PDE9A (0.40) | KDM4ESTAT6NPSR1WHR1MAP4K1 | |
| SCHEMBL21240381 | 0.89 | PDE9A (0.40) | KDM4ESTAT6NPSR1WHR1MAP4K1 | |
| SCHEMBL21252193 | 0.85 | PIK3CA (0.48) | PIK3CAMTORCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL21251737 | 0.84 | HPGD (0.40) | KDM4ESTAT6NPSR1WHR1MAP4K1 | |
| SCHEMBL21252007 | 0.83 | PIK3CA (0.36) | PIK3CAMTORWHR1MAP4K1GAK | |
| SCHEMBL21251668 | 0.83 | NTSR1 (0.39) | PIK3CAMTORKDM4ESTAT6NPSR1 | |
| SCHEMBL24488235 | 0.83 | FGFR1 (0.33) | PIK3CAMTORKDM4ESTAT6NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |