Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20332035 | 0.95 | PDE10A (0.37) | MAOBFGFR4MAP3K12PDE3APDE3B | |
| SCHEMBL21252087 | 0.95 | MAP4K4 (0.39) | PIM1PIM3PIM2MAP4K4MAOB | |
| SCHEMBL20332009 | 0.91 | FGFR4 (0.34) | FGFR4MAP3K12PDE10AFGFR1TTK | |
| SCHEMBL21251873 | 0.89 | PIK3CA (0.37) | MAP4K4FGFR4PDE3APDE3BPDE10A | |
| SCHEMBL24488230 | 0.89 | PDE10A (0.39) | MAOBFGFR4MAP3K12PDE3APDE3B | |
| SCHEMBL21251868 | 0.87 | MAOB (0.37) | PIM1PIM3PIM2MAP4K4MAOB | |
| SCHEMBL20331864 | 0.86 | PDE10A (0.38) | MAOBFGFR4PDE3APDE3BPDE10A | |
| SCHEMBL21251716 | 0.86 | PDE10A (0.38) | MAOBFGFR4PDE3APDE3BPDE10A | |
| SCHEMBL21240510 | 0.86 | MAOB (0.38) | PIM1PIM3PIM2MAP4K4MAOB | |
| SCHEMBL21251762 | 0.85 | FGFR4 (0.37) | FGFR4MAP3K12PDE3APDE3BPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |