Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251783 | 0.95 | PIM1 (0.36) | MAP4K4MAOBHTR6FGFR4PIM1 | |
| SCHEMBL24488230 | 0.94 | PDE10A (0.39) | MAOBFGFR4PDE3BPDE3APDE10A | |
| SCHEMBL21240510 | 0.91 | MAOB (0.38) | MAP4K4MAOBHTR6FGFR4PIM1 | |
| SCHEMBL21251762 | 0.90 | FGFR4 (0.37) | FGFR4PDE3BPDE3APDE10AMAP3K12 | |
| SCHEMBL21251868 | 0.90 | MAOB (0.37) | MAP4K4MAOBHTR6FGFR4PIM1 | |
| SCHEMBL20332035 | 0.89 | PDE10A (0.37) | MAOBFGFR4PDE3BPDE3APDE10A | |
| SCHEMBL21252058 | 0.89 | FGFR4 (0.40) | MAP4K4FGFR4PDE3BPDE3APDE10A | |
| SCHEMBL21252341 | 0.87 | SMN1; SMN2 (0.43) | FGFR4FGFR1FGFR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL21252286 | 0.87 | SMN1; SMN2 (0.40) | FGFR4FGFR1FGFR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL24488354 | 0.85 | MAP4K4 (0.39) | MAP4K4MAOBHTR6PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |