Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 6/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252435 | 0.93 | JAK2 (0.38) | TTKJAK2JAK1TYK2KDR | |
| SCHEMBL24488291 | 0.93 | TTK (0.36) | MAP3K12TTKJAK2JAK1TYK2 | |
| SCHEMBL21252267 | 0.88 | PDE10A (0.36) | TTKJAK2JAK1TYK2KDR | |
| SCHEMBL21252266 | 0.86 | JAK2 (0.36) | MAP3K12JAK2JAK1TYK2KDR | |
| SCHEMBL21252258 | 0.86 | NOS1 (0.42) | JAK2JAK1TYK2KDRJAK3 | |
| SCHEMBL24488267 | 0.86 | JAK2 (0.37) | TTKJAK2JAK1TYK2KDR | |
| SCHEMBL21252520 | 0.85 | JAK2 (0.38) | MAP3K12TTKJAK2JAK1TYK2 | |
| SCHEMBL21252298 | 0.84 | TTK (0.38) | MAP3K12TTKJAK2JAK1TYK2 | |
| SCHEMBL21252085 | 0.83 | TTK (0.38) | MAP3K12TTKJAK2JAK1TYK2 | |
| SCHEMBL21252066 | 0.82 | FGFR1 (0.37) | TTKJAK2JAK1TYK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |