Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | MTOR | P42345 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252286 | 0.90 | SMN1; SMN2 (0.40) | PIK3CAMTORSMN1; SMN2FGFR1ALDH1A1 | |
| SCHEMBL21252341 | 0.90 | SMN1; SMN2 (0.43) | PIK3CAMTORSMN1; SMN2FGFR1MAP2K7 | |
| SCHEMBL20332257 | 0.89 | SMN1; SMN2 (0.48) | PIK3CAMTORSMN1; SMN2FGFR1PDE10A | |
| SCHEMBL21252340 | 0.88 | PIK3CA (0.47) | PIK3CAMTORSMN1; SMN2FGFR1PDE10A | |
| SCHEMBL21251915 | 0.87 | TTK (0.37) | PIK3CAMTORSMN1; SMN2FGFR1FGFR3 | |
| SCHEMBL21252329 | 0.86 | GAK (0.40) | PIK3CAMTORSMN1; SMN2FGFR1PDE10A | |
| SCHEMBL21252058 | 0.86 | FGFR4 (0.40) | PIK3CAMTORFGFR1PDE10A | |
| SCHEMBL21252481 | 0.86 | FGFR4 (0.40) | FGFR1 | |
| SCHEMBL21252093 | 0.85 | PDE10A (0.38) | PIK3CAMTORFGFR1PDE10AFGFR3 | |
| SCHEMBL21251782 | 0.85 | PIK3CA (0.36) | PIK3CAMTORSMN1; SMN2FGFR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |