Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.47 |
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | GAK | O14976 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240308 | 0.88 | SMN1; SMN2 (0.47) | MTORGAKSMN1; SMN2PDE10ATRPM8 | |
| SCHEMBL20331064 | 0.88 | GAK (0.42) | MTORGAKSMN1; SMN2PDE10ATRPM8 | |
| SCHEMBL21252344 | 0.88 | PIK3CA (0.47) | PIK3CAMTORGAKSMN1; SMN2PDE10A | |
| SCHEMBL21252468 | 0.86 | LRRK2 (0.42) | PIK3CAMTORGAKPDE10ALRRK2 | |
| SCHEMBL21252174 | 0.86 | PIK3CA (0.37) | PIK3CAMTOR | |
| SCHEMBL21252007 | 0.85 | PIK3CA (0.36) | PIK3CAMTORGAKMAP4K1 | |
| SCHEMBL21252008 | 0.85 | GAK (0.37) | PIK3CAMTORGAKPIK3R1 | |
| SCHEMBL21252220 | 0.84 | PIK3CA (0.33) | PIK3CAMTORMAP4K1FGFR4 | |
| SCHEMBL21252176 | 0.84 | MTOR (0.39) | PIK3CAMTORGAKKDM4EALDH1A1 | |
| SCHEMBL21252083 | 0.83 | PDE10A (0.34) | PIK3CAMTORPDE10AMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |