Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 11/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251976 | 0.79 | FGFR1 (0.50) | FGFR1FGFR4PDGFRBPDGFRAFGFR2 | |
| SCHEMBL21251769 | 0.78 | FGFR1 (0.57) | FGFR1FGFR4PDGFRAFGFR2FGFR3 | |
| SCHEMBL20330520 | 0.76 | FGFR1 (0.65) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL30044812 | 0.76 | FGFR1 (0.65) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL24488253 | 0.72 | FGFR1 (0.35) | FGFR1FGFR4EGFRPDGFRBPDGFRA | |
| SCHEMBL21251808 | 0.70 | FGFR1 (0.49) | FGFR1FGFR4PDGFRBPDGFRAFGFR2 | |
| SCHEMBL30046401 | 0.69 | FGFR1 (0.66) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL20330528 | 0.69 | FGFR1 (0.66) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL20330516 | 0.67 | FGFR4 (0.74) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL30045115 | 0.67 | FGFR4 (0.74) | FGFR1FGFR4FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |