Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | JMJD6 | Q6NYC1 | 5/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21257729 | 0.82 | KDM5C (0.42) | KDM5CKDM4CPIK3CAJMJD6KDM5B | |
| SCHEMBL21257580 | 0.76 | PIK3CA (0.41) | KDM5CKDM4CPIK3CAJMJD6KDM5B | |
| SCHEMBL21257697 | 0.76 | PIK3CA (0.46) | KDM5CKDM4CPIK3CAJMJD6KDM5B | |
| SCHEMBL17145118 | 0.74 | JMJD6 (0.46) | KDM5CKDM4CPIK3CAJMJD6KDM5B | |
| SCHEMBL21257802 | 0.73 | JMJD6 (0.43) | KDM5CKDM4CPIK3CAJMJD6KDM5B | |
| SCHEMBL21257814 | 0.73 | KDM5B (0.48) | KDM5CKDM4CPIK3CAJMJD6KDM5B | |
| SCHEMBL15726745 | 0.71 | PIK3CA (0.50) | KDM5CKDM4CPIK3CAJMJD6KDM5B | |
| SCHEMBL3727609 | 0.71 | JMJD6 (0.56) | KDM5CKDM4CPIK3CAJMJD6KDM5B | |
| SCHEMBL14825403 | 0.71 | OPRD1 (0.58) | KDM5CKDM4CPIK3CAKDM4EALDH1A1 | |
| SCHEMBL21257715 | 0.71 | KDM5B (0.47) | KDM5CKDM4CPIK3CAJMJD6KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019154261-A1 | PYRIDINE DERIVATIVE RELATED TO KMD5 PATHWAY | 南京明德新药研发股份有限公司 | 2019-08-15 | — | — | WO | disclosed |