Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21262167 | 1.00 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNB4CHRNA3HTR1A | |
| Hydrochloric Acid SCHEMBL5041501 | 0.98 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3HTR1A | |
| SCHEMBL3568341 | 0.94 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNB4CHRNA3HTR1A | |
| Hydrochloric Acid SCHEMBL3578509 | 0.92 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3HTR1A | |
| SCHEMBL26938918 | 0.80 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3PDE10A | |
| SCHEMBL13103511 | 0.80 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3PDE10A | |
| SCHEMBL20468889 | 0.80 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3RET | |
| Hydrochloric Acid SCHEMBL20491840 | 0.79 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3RET | |
| Hydrochloric Acid SCHEMBL29882451 | 0.79 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3HTR1A | |
| SCHEMBL22129422 | 0.77 | PDE10A (0.50) | HTR1ADRD4HTR2ASLC6A4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11518764-B2 | Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-12-06 | — | — | US | disclosed |
| US-20200331921-A1 | INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2020-10-22 | — | — | US | disclosed |
| WO-2019153080-A1 | INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11518764-B2 | Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction | BCL6, BCL6B, BCL3 | CHRNB2 4817/4885CHRNA4 4875/4885CHRNB4 4833/4885 |
| US-20200331921-A1 | INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | BCL6, BCL6B, BCL3 | CHRNB2 4816/4885CHRNA4 4871/4885CHRNB4 4837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.