Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | TOP2A | P11388 | 1/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | F3 | P13726 | 3/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.46 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.46 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.46 |
| ▸ | PTPRC | P08575 | 2/20 | 0.46 |
| ▸ | PTPRF | P10586 | 2/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.46 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.46 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Taraxerol SCHEMBL14047708 | 1.00 | PTPN1 (1.00) | PTPN1USP2TOP2AAKR1B10AKR1B1 | |
| Taraxerol SCHEMBL569463 | 1.00 | PTPN1 (1.00) | PTPN1USP2TOP2AAKR1B10AKR1B1 | |
| Taraxerol SCHEMBL15491005 | 1.00 | PTPN1 (1.00) | PTPN1USP2TOP2AAKR1B10AKR1B1 | |
| Taraxerol SCHEMBL15491002 | 1.00 | PTPN1 (1.00) | PTPN1USP2TOP2AAKR1B10AKR1B1 | |
| Taraxerol SCHEMBL569464 | 1.00 | PTPN1 (1.00) | PTPN1USP2TOP2AAKR1B10AKR1B1 | |
| SCHEMBL4202103 | 0.83 | PTPN1 (0.71) | PTPN1USP2TOP2AAKR1B10AKR1B1 | |
| SCHEMBL19473411 | 0.83 | PTPN1 (0.71) | PTPN1USP2TOP2APOLBPTPN2 | |
| SCHEMBL29759467 | 0.83 | PTPN1 (0.71) | PTPN1USP2TOP2APOLBPTPN2 | |
| Aleuritolic Acid SCHEMBL438408 | 0.82 | PTPN1 (0.70) | PTPN1USP2AKR1B10POLBF3 | |
| SCHEMBL23929102 | 0.81 | PTPN1 (0.67) | PTPN1USP2POLBPTPN2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11660306-B2 | Treatment of Rett syndrome | COLD SPRING HARBOR LABORATORY (US) | 2023-05-30 | — | — | US | disclosed |
| US-11660306-B2 | Treatment of Rett syndrome | COLD SPRING HARBOR LABORATORY (US) | 2023-05-30 | — | — | US | disclosed |
| US-20190247408-A1 | TREATMENT OF RETT SYNDROME | COLD SPRING HARBOR LABORATORY (US) | 2019-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190247408-A1 | TREATMENT OF RETT SYNDROME | MECP2, BDNF, NTRK2 | PTPN1 4223/4885USP2 1781/4885TOP2A 3561/4885 |
| US-11660306-B2 | Treatment of Rett syndrome | MECP2, BDNF, NTRK2 | PTPN1 4223/4885USP2 1781/4885TOP2A 3561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.