Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 19/20 | 0.58 |
| ▸ | CDK4 | P11802 | 15/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.58 |
| ▸ | CDK2 | P24941 | 6/20 | 0.58 |
| ▸ | CSF1R | P07333 | 5/20 | 0.58 |
| ▸ | CCND3 | P30281 | 10/20 | 0.47 |
| ▸ | CDK1 | P06493 | 5/20 | 0.47 |
| ▸ | CCND1 | P24385 | 5/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.47 |
| ▸ | CCNK | O75909 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | STK16 | O75716 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21267353 | 0.94 | CDK6 (0.62) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267582 | 0.90 | CDK6 (0.71) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267930 | 0.89 | CDK6 (0.57) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267357 | 0.88 | CDK6 (0.57) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267590 | 0.83 | CDK6 (0.62) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267540 | 0.82 | CDK6 (0.51) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267530 | 0.82 | CDK6 (0.63) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267617 | 0.81 | CDK6 (0.53) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267232 | 0.81 | CDK4 (0.52) | CDK6CDK4CCNA2CDK2CSF1R | |
| SCHEMBL21267880 | 0.80 | CDK6 (0.52) | CDK6CDK4CCNA2CDK2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230062022-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | NUVATION BIO INC (US) | 2023-03-02 | — | — | US | disclosed |
| US-11174252-B2 | Heterocyclic compounds as kinase inhibitors | NUVATION BIO INC. (US) | 2021-11-16 | — | — | US | disclosed |
| US-20190248774-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2019-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174252-B2 | Heterocyclic compounds as kinase inhibitors | CDK6, CDK4, CDK9 | CDK6 1/4885CDK4 2/4885CCNA2 33/4885 |
| US-20190248774-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | CDK4, CDK6, CDK8 | CDK6 2/4885CDK4 1/4885CCNA2 38/4885 |
| US-20230062022-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | CDK4, CDK6, CDK8 | CDK6 2/4885CDK4 1/4885CCNA2 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.