Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16197671 | 1.00 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3KCNH2CHRM1 | |
| SCHEMBL21268108 | 1.00 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3KCNH2CHRM1 | |
| SCHEMBL16197334 | 1.00 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3KCNH2CHRM1 | |
| SCHEMBL16208507 | 1.00 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3KCNH2CHRM1 | |
| SCHEMBL17583776 | 1.00 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3KCNH2CHRM1 | |
| SCHEMBL16197260 | 1.00 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3KCNH2CHRM1 | |
| SCHEMBL21278134 | 1.00 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3KCNH2CHRM1 | |
| SCHEMBL21268109 | 0.87 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3SMN1; SMN2KDM4E | |
| SCHEMBL16197372 | 0.87 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3SMN1; SMN2KDM4E | |
| SCHEMBL16197282 | 0.87 | SIGMAR1 (1.00) | SIGMAR1GAAHRH3SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2989104-B1 | PYRAZINO[1,2-A]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS SA (ES) | 2019-08-21 | — | — | EP | claimed |