Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8717934 | 0.79 | OPRM1 (0.44) | OPRM1OPRL1PSEN1PSEN2APH1B | |
| SCHEMBL8703203 | 0.78 | OPRM1 (0.44) | OPRM1OPRL1PSEN1PSEN2APH1B | |
| SCHEMBL28331193 | 0.76 | TACR1 (0.40) | OPRM1OPRL1DPP4MEN1ALDH1A1 | |
| SCHEMBL27783290 | 0.76 | OPRM1 (0.38) | OPRM1OPRL1PSEN1PSEN2APH1B | |
| SCHEMBL24792758 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1PSEN1PSEN2APH1B | |
| SCHEMBL24792755 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1PSEN1PSEN2APH1B | |
| SCHEMBL24792756 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1PSEN1PSEN2APH1B | |
| SCHEMBL30137974 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1PSEN1PSEN2APH1B | |
| SCHEMBL12557616 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1PSEN1PSEN2APH1B | |
| SCHEMBL24792759 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2442809-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Incorporated (US) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010148197-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-23 | — | — | WO | disclosed |