Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 18/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23725735 | 1.00 | IRAK4 (0.42) | IRAK4IRAK1MGLL | |
| SCHEMBL9994585 | 0.85 | MGLL (0.41) | IRAK4IRAK1MGLL | |
| SCHEMBL9994588 | 0.84 | MGLL (0.40) | IRAK4IRAK1MGLL | |
| SCHEMBL18009354 | 0.81 | MGLL (0.39) | IRAK4IRAK1MGLL | |
| SCHEMBL1715768 | 0.79 | — | — | |
| SCHEMBL19973031 | 0.79 | — | — | |
| SCHEMBL18014839 | 0.76 | HCAR2 (0.40) | IRAK4IRAK1MGLL | |
| SCHEMBL18009241 | 0.74 | HCAR2 (0.38) | IRAK4IRAK1MGLL | |
| SCHEMBL18009250 | 0.74 | HCAR2 (0.38) | IRAK4IRAK1MGLL | |
| SCHEMBL18009233 | 0.74 | HCAR2 (0.38) | IRAK4IRAK1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084940-A | PD-1/PD-L1 inhibitors | 吉利德科学公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117412959-A | Substituted 1-aryl-1 '-heteroaryl compounds, substituted 1,1' -biaryl compounds, and methods of use thereof | 爱彼特生物制药公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-112041311-B | PD-1/PD-L1 inhibitors | 吉利德科学公司 | 2023-10-03 | — | — | CN | disclosed |
| EP-4227302-A1 | PD-1/PD-L1 INHIBITORS | Gilead Sciences, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| US-20230212155-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. | 2023-07-06 | — | — | US | disclosed |
| EP-4169925-A2 | PROCESS TO MAKE N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES | Novartis AG (CH) | 2023-04-26 | — | — | EP | disclosed |
| EP-3752501-B1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES INC (US) | 2023-04-19 | — | — | EP | disclosed |
| US-11555029-B2 | PD-1/PD-L1 inhibitors | GILEAD SCIENCES, INC. (US) | 2023-01-17 | — | — | US | disclosed |
| CN-115413275-A | Substituted 1,1 , -biphenyl compounds and methods of use thereof | 爱彼特生物制药公司 | 2022-11-29 | — | — | CN | disclosed |
| US-20210053946-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2021-02-25 | — | — | US | disclosed |
| EP-3752501-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2020-12-23 | — | — | EP | disclosed |
| CN-112041311-A | PD-1/PD-L1 inhibitors | 吉利德科学公司 | 2020-12-04 | — | — | CN | disclosed |
| CN-111712494-A | PD-1/PD-L1 inhibitors | 吉利德科学公司 | 2020-09-25 | — | — | CN | disclosed |
| US-10710986-B2 | PD-1/PD-L1 inhibitors | GILEAD SCIENCES, INC. (US) | 2020-07-14 | — | — | US | disclosed |
| US-20190270727-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. | 2019-09-05 | — | — | US | disclosed |
| WO-2019160882-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2019-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11555029-B2 | PD-1/PD-L1 inhibitors | PDCD1, CD274, PDCD1LG2 | IRAK4 1881/4885IRAK1 1253/4885MGLL 1243/4885 |
| US-20230212155-A1 | PD-1/PD-L1 INHIBITORS | PDCD1, CD274, PDCD1LG2 | IRAK4 1881/4885IRAK1 1253/4885MGLL 1243/4885 |
| US-20210053946-A1 | PD-1/PD-L1 INHIBITORS | PDCD1, CD274, PDCD1LG2 | IRAK4 1881/4885IRAK1 1253/4885MGLL 1243/4885 |
| US-10710986-B2 | PD-1/PD-L1 inhibitors | PDCD1, CD274, PDCD1LG2 | IRAK4 1881/4885IRAK1 1253/4885MGLL 1243/4885 |
| US-20190270727-A1 | PD-1/PD-L1 INHIBITORS | PDCD1, CD274, PDCD1LG2 | IRAK4 1881/4885IRAK1 1253/4885MGLL 1243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.