Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 10/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 6/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 6/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28539899 | 1.00 | ATR (0.55) | ATRPDE4DPIK3CDPIK3CAMTOR | |
| SCHEMBL29442179 | 1.00 | ATR (0.55) | ATRPDE4DPIK3CDPIK3CAMTOR | |
| SCHEMBL28539901 | 1.00 | ATR (0.55) | ATRPDE4DPIK3CDPIK3CAMTOR | |
| SCHEMBL28543249 | 0.85 | ATR (0.42) | ATRPDE4DPIK3CDPIK3CAMTOR | |
| SCHEMBL28543248 | 0.85 | ATR (0.42) | ATRPDE4DPIK3CDPIK3CAMTOR | |
| SCHEMBL27578290 | 0.81 | KDM4E (0.43) | ATRPDE4DMTORPIK3C3KDM4E | |
| SCHEMBL27517643 | 0.81 | KDM4E (0.43) | ATRPDE4DMTORKDM4EALDH1A1 | |
| SCHEMBL27833947 | 0.80 | MTOR (0.51) | ATRPDE4DPIK3CDPIK3CAMTOR | |
| SCHEMBL29947221 | 0.80 | PIK3CA (0.50) | ATRPDE4DPIK3CDPIK3CAMTOR | |
| SCHEMBL28958536 | 0.80 | PIK3CA (0.50) | ATRPDE4DPIK3CDPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278103-B2 | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators | Grünenthal GmbH (DE) | 2016-03-08 | — | — | US | disclosed |
| US-9168259-B2 | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators | Grünenthal GmbH (DE) | 2015-10-27 | — | — | US | disclosed |
| EP-2807172-A1 | PYRIMIDOOXAZOCINE DERIVATIVES AS MTOR - INHIBITORS | SANOFI (FR) | 2014-12-03 | — | — | EP | disclosed |
| US-20140213569-A1 | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators | GRUNENTHAL GMBH (DE) | 2014-07-31 | — | — | US | disclosed |
| US-8552200-B2 | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-10-08 | — | — | US | disclosed |
| WO-2013111106-A1 | PYRIMIDOOXAZOCINE DERIVATIVES AS MTOR - INHIBITORS | SANOFI (FR) | 2013-08-01 | — | — | WO | disclosed |
| US-20120258947-A1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2012-10-11 | — | — | US | disclosed |
| US-20120101079-A1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213569-A1 | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators | KCNQ2, KCNQ1, KCNQ3 | ATR 4075/4885PDE4D 1280/4885PIK3CD 1446/4885 |
| US-20120101079-A1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | KCNQ2, KCNQ1, KCNQ3 | ATR 4075/4885PDE4D 1280/4885PIK3CD 1446/4885 |
| US-20120258947-A1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | KCNQ2, KCNQ1, KCNQ3 | ATR 4075/4885PDE4D 1280/4885PIK3CD 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.