Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21275145 | 0.90 | BTK (0.44) | BTKJAK3EGFR | |
| SCHEMBL22712703 | 0.90 | BTK (0.44) | BTKJAK3EGFR | |
| SCHEMBL26103638 | 0.82 | EGFR (0.42) | BTKJAK3EGFR | |
| SCHEMBL26103631 | 0.82 | EGFR (0.42) | BTKJAK3EGFR | |
| SCHEMBL21275146 | 0.80 | SCN9A (0.42) | BTKJAK3 | |
| SCHEMBL22712689 | 0.80 | SCN9A (0.42) | BTKJAK3 | |
| SCHEMBL21275137 | 0.77 | BTK (0.55) | BTKJAK3EGFR | |
| SCHEMBL21275177 | 0.77 | OPRM1 (0.34) | BTKJAK3EGFR | |
| SCHEMBL23165013 | 0.76 | EGFR (0.53) | JAK3EGFR | |
| SCHEMBL22712691 | 0.76 | JAK2 (0.51) | BTKJAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3755702-A1 | INHIBITORS OF BTK AND MUTANTS THEREOF | Newave Pharmaceutical Inc. (US) | 2020-12-30 | — | — | EP | disclosed |
| WO-2019161152-A1 | INHIBITORS OF BTK AND MUTANTS THEREOF | NEWAVE PHARMACEUTICAL INC. (US) | 2019-08-22 | — | — | WO | disclosed |