Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GCKR | Q14397 | 5/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23104482 | 0.83 | CHRNB2 (0.44) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL23089144 | 0.83 | CHRNB2 (0.44) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL29814518 | 0.83 | CHRNB2 (0.44) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL619825 | 0.75 | MAPT (0.49) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL29891246 | 0.75 | MAPT (0.49) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL13769145 | 0.74 | CDK1 (0.49) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL4528273 | 0.74 | CDK1 (0.49) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL29618159 | 0.74 | CDK1 (0.49) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL4721289 | 0.74 | CDK1 (0.49) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA | |
| SCHEMBL23089266 | 0.71 | MAPT (0.45) | CHRNB2CHRNA4ALOX5APFEN1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752491-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019161224-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | GiraFpharma LLC (US) | 2019-08-22 | — | — | WO | disclosed |