Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 17/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21276775 | 0.80 | RET (0.50) | — | |
| SCHEMBL21276820 | 0.77 | CHRNB2 (0.32) | APPCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL21276762 | 0.75 | APP (0.47) | APPCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL17443376 | 0.72 | RET (0.50) | — | |
| SCHEMBL21276683 | 0.71 | RET (0.49) | — | |
| SCHEMBL17443400 | 0.70 | FLT3 (0.48) | — | |
| SCHEMBL21276748 | 0.69 | RET (0.54) | — | |
| SCHEMBL21276719 | 0.69 | HRH3 (0.48) | — | |
| SCHEMBL21276767 | 0.67 | FLT3 (0.50) | — | |
| SCHEMBL18763426 | 0.67 | HRH3 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169671-B1 | 1-(5-(TERT.-BUTYL)ISOXAZOL-3-YL)-3-(4-((PHENYL)ETHYNYL)PHENYL)UREA DERIVATIVES AND RELATED COMPOUNDS AS FLT3 INHIBITORS FOR TREATING CANCER | SUNSHINE LAKE PHARMA CO LTD (CN) | 2019-08-21 | — | — | EP | disclosed |