Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21276713 | 0.89 | HRH3 (0.42) | MAPK1HRH3ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL21276712 | 0.84 | ACACB (0.41) | HRH3ALDH1A1CYP1A2HRH2HRH1 | |
| SCHEMBL17447637 | 0.81 | RET (0.60) | KDR | |
| SCHEMBL17447611 | 0.77 | RET (0.59) | KDR | |
| SCHEMBL21276751 | 0.77 | HRH3 (0.54) | MAPK1HRH3ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL21276831 | 0.74 | MAP2K1 (0.40) | MAPK1HRH3ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL21276746 | 0.74 | TSHR (0.51) | MAPK1HRH3ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL113405 | 0.70 | LTA4H (0.63) | MAPK1HRH3ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL22747642 | 0.70 | NPC1 (0.49) | MAPK1HRH3ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL18763485 | 0.70 | RET (0.41) | MAPK1HRH3ALDH1A1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169671-B1 | 1-(5-(TERT.-BUTYL)ISOXAZOL-3-YL)-3-(4-((PHENYL)ETHYNYL)PHENYL)UREA DERIVATIVES AND RELATED COMPOUNDS AS FLT3 INHIBITORS FOR TREATING CANCER | SUNSHINE LAKE PHARMA CO LTD (CN) | 2019-08-21 | — | — | EP | disclosed |