Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 18/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17767754 | 0.82 | TGFBR1 (0.69) | TGFBR1MAPK14 | |
| SCHEMBL14576284 | 0.82 | TGFBR1 (1.00) | TGFBR1MAPK14MTOR | |
| SCHEMBL30203933 | 0.82 | TGFBR1 (1.00) | TGFBR1MAPK14MTOR | |
| SCHEMBL17767719 | 0.81 | TGFBR1 (0.57) | TGFBR1MAPK14PDE10A | |
| SCHEMBL21277990 | 0.81 | TGFBR1 (0.62) | TGFBR1MAPK14MTORKDR | |
| SCHEMBL17767428 | 0.81 | TGFBR1 (0.68) | TGFBR1MAPK14PDE10A | |
| SCHEMBL30203968 | 0.80 | TGFBR1 (1.00) | TGFBR1MAPK14MTOR | |
| SCHEMBL14576531 | 0.80 | TGFBR1 (1.00) | TGFBR1MAPK14MTOR | |
| SCHEMBL17767792 | 0.78 | TGFBR1 (0.48) | TGFBR1PDE10A | |
| SCHEMBL17767422 | 0.77 | TGFBR1 (0.47) | TGFBR1MAPK14PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527570-A1 | FIVE-MEMBERED HETEROARYL RING BRIDGED RING DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2019-08-21 | — | — | EP | disclosed |