SCHEMBL21279080

SCHEMBL21279080

Cc1cc(-c2cc(-n3c4ccccc4c4ccc(-c5ccccc5C)cc43)c(C#N)c(-n3c4ccccc4c4ccc(-c5ccccc5C)cc43)c2)nc(C)n1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
AR P10275 1/20 0.33
PIP4K2A P48426 1/20 0.33
PIM1 P11309 1/20 0.32
SQOR Q9Y6N5 5/20 0.32
KDM4E B2RXH2 2/20 0.32
HPGD P15428 2/20 0.32
ADORA2A P29274 2/20 0.32
ADORA1 P30542 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
PPARG P37231 1/20 0.32
NCOA2 Q15596 1/20 0.32
NCOA1 Q15788 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
NCOA3 Q9Y6Q9 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TRPA1 O75762 1/20 0.32
LMNA P02545 2/20 0.32
GAA P10253 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21279078 0.97 ALDH1A1 (0.35) ALDH1A1ARPIP4K2APIM1SQOR
SCHEMBL19909433 0.89 AR (0.36) ALDH1A1ARPIP4K2AKDM4EHPGD
SCHEMBL21278713 0.88 ALDH1A1 (0.32) ALDH1A1SQORKDM4EHPGDADORA2A
SCHEMBL21279147 0.87 ALDH1A1 (0.35) ALDH1A1PIM1KDM4EHPGDADORA2A
SCHEMBL21279085 0.87 CHEK1 (0.35) ALDH1A1
SCHEMBL22563691 0.87 AR (0.35) ALDH1A1ARPIP4K2ASQORKDM4E
SCHEMBL19942676 0.87 AR (0.35) ALDH1A1ARPIP4K2ASQORKDM4E
SCHEMBL21278835 0.87 ALDH1A1 (0.34) ALDH1A1SQORKDM4EHPGDADORA2A
SCHEMBL21279127 0.87 KDM4E (0.35) ALDH1A1SQORKDM4EHPGDADORA2A
SCHEMBL21279087 0.86 ALDH1A1 (0.31) ALDH1A1SQORKDM4EHPGDADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3399004-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-08-21 EP disclosed