SCHEMBL21279082

SCHEMBL21279082

Cc1cccc(-c2ccc3c4ccc(-c5cccc(C)c5)cc4n(-c4cc(-c5cc(C)nc(C)n5)cc(-n5c6cc(-c7cccc(C)c7)ccc6c6ccc(-c7cccc(C)c7)cc65)c4C#N)c3c2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.41
ADORA1 P30542 3/20 0.41
KDM4A O75164 1/20 0.39
KDM5B Q9UGL1 1/20 0.39
ALDH1A1 P00352 5/20 0.36
HPGD P15428 4/20 0.36
MEN1 O00255 1/20 0.36
POLB P06746 1/20 0.36
KMT2A Q03164 1/20 0.36
CTSS P25774 1/20 0.36
CTSK P43235 1/20 0.36
PIP4K2A P48426 1/20 0.36
KDM4E B2RXH2 4/20 0.35
ADORA2B P29275 1/20 0.35
PPARG P37231 1/20 0.34
NCOA2 Q15596 1/20 0.34
NCOA1 Q15788 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
NCOA3 Q9Y6Q9 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21279076 0.96 ADORA2A (0.40) ADORA2AADORA1KDM4AKDM5BALDH1A1
SCHEMBL21279068 0.91 ALDH1A1 (0.39) ADORA2AADORA1KDM4AKDM5BALDH1A1
SCHEMBL21279125 0.89 KDM4E (0.33) ADORA2AADORA1ALDH1A1HPGDMEN1
SCHEMBL19909437 0.88 KDM5B (0.42) ADORA2AADORA1KDM4AKDM5BALDH1A1
SCHEMBL21279095 0.87 CHEK1 (0.38) ALDH1A1MEN1KMT2A
SCHEMBL21278728 0.86 ALDH1A1 (0.37) ADORA2AADORA1ALDH1A1HPGDMEN1
SCHEMBL21278729 0.86 IRAK4 (0.33)
SCHEMBL21279127 0.86 KDM4E (0.35) ADORA2AADORA1ALDH1A1HPGDKDM4E
SCHEMBL19942681 0.86 KDM5B (0.41) ADORA2AADORA1KDM4AKDM5BALDH1A1
SCHEMBL22563586 0.86 KDM4A (0.41) ADORA2AADORA1KDM4AKDM5BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3399004-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-08-21 EP disclosed