SCHEMBL21279102

SCHEMBL21279102

N#Cc1cc(-n2c3ccccc3c3cc(C#N)ccc32)c(-c2cc(-c3ccccc3)nc(-c3ccccc3)n2)c(-n2c3ccccc3c3cc(C#N)ccc32)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 8/20 0.43
ABCB1 P08183 3/20 0.39
MEN1 O00255 5/20 0.38
KMT2A Q03164 5/20 0.38
CYP1A2 P05177 5/20 0.38
ALDH1A1 P00352 4/20 0.38
LMNA P02545 4/20 0.38
CYP3A4 P08684 4/20 0.38
CLK4 Q9HAZ1 3/20 0.38
TSHR P16473 3/20 0.38
CYP2D6 P10635 3/20 0.38
CYP2C19 P33261 2/20 0.38
HSD17B10 Q99714 2/20 0.38
CYP2C9 P11712 1/20 0.38
JAK2 O60674 1/20 0.37
PRKD3 O94806 1/20 0.37
ABL1 P00519 1/20 0.37
EGFR P00533 1/20 0.37
ERBB2 P04626 1/20 0.37
LCK P06239 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21279070 0.97 ABCG2 (0.45) ABCG2ABCB1MEN1KMT2ACYP1A2
SCHEMBL22563499 0.93 ABCG2 (0.43) ABCG2ABCB1MEN1KMT2ACYP1A2
SCHEMBL21279106 0.93 ABCG2 (0.43) ABCG2ABCB1MEN1KMT2AALDH1A1
SCHEMBL21279103 0.92 ABCG2 (0.40) ABCG2ABCB1MEN1KMT2ACYP1A2
SCHEMBL21278970 0.92 ALDH1A3 (0.43) ABCG2MEN1KMT2ACYP1A2ALDH1A1
SCHEMBL21279054 0.91 ABCG2 (0.39) ABCG2ABCB1MEN1KMT2ACYP1A2
SCHEMBL21279055 0.91 ABCG2 (0.39) ABCG2ABCB1MEN1KMT2ACYP1A2
SCHEMBL21279006 0.90 ABCG2 (0.38) ABCG2ABCB1MEN1KMT2ACYP1A2
SCHEMBL21108013 0.90 ABCG2 (0.42) ABCG2ABCB1MEN1KMT2ACYP1A2
SCHEMBL22563431 0.90 ABCG2 (0.44) ABCG2ABCB1MEN1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3399004-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-08-21 EP disclosed