Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2737941 | 1.00 | MAPT (0.40) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL9986315 | 0.88 | ALDH1A1 (0.37) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL223010 | 0.88 | ALDH1A1 (0.37) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL22164216 | 0.86 | PARP1 (0.35) | KDM4EALDH1A1HTTNPSR1PLAT | |
| SCHEMBL2737949 | 0.85 | ALDH1A1 (0.39) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL17823266 | 0.85 | ALDH1A1 (0.39) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL2738092 | 0.84 | ALDH1A1 (0.38) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL220358 | 0.83 | ALDH1A1 (0.37) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL9986923 | 0.83 | ALDH1A1 (0.37) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL21279703 | 0.81 | ALDH1A1 (0.36) | MAPTKDM4ETHRBALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2838900-B1 | COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES INC (US) | 2019-08-21 | — | — | EP | disclosed |